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KMID : 0616120110420010046
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 1 p.46 ~ p.53
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Screening of Herbal Medicines from China with Inhibitory Activity on Advanced Glycation End Products (AGEs) Formation (V)
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Kim Young-Sook
Choi Sung-Hoon
Kim Joo-Hwan
Kim Jin-Sook
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Abstract
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Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 66 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 31 herbal medicines (IC50<50 μg/ml) were found to have significant AGEs formation inhibitory activity. Particularly, 5 herbal medicines, Camptotheca acuminata (branches and leaves), Quercus franchetii (branches), Camellia pitardii (leaves, branches, and fruits), Antidesma bunius (whole plants), and Loranthus parasiticus (whole plants) showed more potent inhibitory activity (approximately 6-20 fold) than the positive control aminoguanidine (IC50=52.96 μg/ml).
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KEYWORD
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Advanced glycation end products (AGEs), Diabetic complications, Herbal medicines
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